Being Bayer Leverkusen’s most promising and (probably) best player, Wirtz recorded the highest average rating among Ms and Ws in this competition.
| Player | Rating | Defense | Minutes Played | Team |
| Florian Wirtz | 8.51 | Back 5 | 542 | Bayer Leverkusen |
| Anastasios Bakasetas | 8.50 | Back 4 | 463 | Trabzonspor |
| Guélor Kanga | 8.41 | Back 4 | 320 | Red Star Belgrade |
| Teddy Teuma | 8.36 | Back 5 | 772 | Union SG |
| Vincenzo Grifo | 8.33 | Back 4 | 382 | Freiburg |
| Cody Gakpo | 8.26 | Back 4 | 368 | PSV Eindhoven |
| Ismail Yuksek | 8.23 | Back 5 | 270 | Fenerbahçe |
| Pedro Gonçalves | 8.18 | Back 5 | 542 | Sporting CP |
| Adrien Rabiot | 8.13 | Back 5 | 570 | Juventus |
| Evander | 8.08 | Back 4 | 512 | Midtjylland |
| Orkun Kökçü | 7.94 | Back 4 | 864 | Feyenoord |
| Manuel Ugarte | 7.94 | Back 5 | 368 | Sporting CP |
| Ludovic Blas | 7.88 | Back 4 | 270 | Nantes |
| Ivan Rakitić | 7.84 | Back 5 | 270 | Sevilla |
| Brais Méndez | 7.77 | Back 4 | 530 | Real Sociedad |
| Abdellah Zoubir | 7.70 | Back 4 | 539 | Qarabağ FK |
| Exequiel Palacios | 7.70 | Back 5 | 424 | Bayer Leverkusen |
| Bruno Fernandes | 7.67 | Back 4 | 863 | Manchester United |
| Ivan Rakitić | 7.67 | Back 4 | 510 | Sevilla |
| Lovro Majer | 7.66 | Back 4 | 513 | Rennes |
| Cauly Souza | 7.59 | Back 4 | 536 | Ludogorets |
| Kady Borges | 7.59 | Back 4 | 511 | Qarabağ FK |
| David Silva | 7.57 | Back 4 | 350 | Real Sociedad |
| Luis Alberto | 7.56 | Back 4 | 307 | Lazio |
| Ibrahim Sangaré | 7.54 | Back 4 | 512 | PSV Eindhoven |
| Ritsu Doan | 7.52 | Back 4 | 374 | Freiburg |
| Youssouf Fofana | 7.45 | Back 4 | 480 | Monaco |
| Joey Veerman | 7.42 | Back 4 | 615 | PSV |
| Ricardo Horta | 7.40 | Back 4 | 504 | Braga |
| Oussama Idrissi | 7.35 | Back 4 | 400 | Feyenoord |
| Manuel Locatelli | 7.33 | Back 5 | 522 | Juventus |
| Casemiro | 7.32 | Back 4 | 987 | Man. United |
| Xavi Simons | 7.32 | Back 4 | 464 | PSV |
| Lorenzo Pellegrini | 7.31 | Back 5 | 1070 | Roma |
| Martin Terrier | 7.30 | Back 4 | 281 | Rennes |
| Paulo Dybala | 7.30 | Back 5 | 452 | Roma |
| Nemanja Matić | 7.27 | Back 5 | 1139 | Roma |
| Alireza Jahanbakhsh | 7.22 | Back 4 | 613 | Feyenoord |
| Rodrigo | 7.22 | Back 4 | 405 | Real Betis |
| Al Musrati | 7.21 | Back 4 | 418 | Braga |
| Granit Xhaka | 7.19 | Back 4 | 569 | Arsenal |
| Marcus Edwards | 7.19 | Back 5 | 526 | Sporting CP |
| Sambi Lokonga | 7.12 | Back 4 | 475 | Arsenal |
| Alexander Prass | 7.12 | Back 4 | 533 | Sturm Graz |
| Nicolas Höfler | 7.12 | Back 4 | 446 | Freiburg |
| Krépin Diatta | 7.07 | Back 4 | 422 | Monaco |
| Lucas Ocampos | 7.06 | Back 4 | 402 | Sevilla |
| Mikel Merino | 7.06 | Back 4 | 541 | Real Sociedad |
| Felipe Anderson | 7.04 | Back 4 | 437 | Lazio |
| Gara Garayev | 7.04 | Back 4 | 397 | Qarabağ FK |
| Sergio Canales | 7.03 | Back 4 | 483 | Real Betis |
| Jakub Piotrowski | 7.01 | Back 4 | 498 | Ludogorets |
| Moussa Diaby | 7.00 | Back 5 | 492 | Bayer Leverkusen |
Conditions for the presented data:
– Minimum minutes played in the season: 270 minutes (equivalent to 3 full games) per type of defense played (Back 4 or Back 5);
– EL Qualifying Round data excluded;
Data from FBref.