With a list featuring players from a number of different teams, Serie A had some quality CFs in the 21-22 season.
| Player | Rating | Defense | Minutes Played | Team |
| Paulo Dybala | 8.33 | Back 4 | 1229 | Juventus |
| Luis Muriel | 8.05 | Back 5 | 1027 | Atalanta |
| Duván Zapata | 7.77 | Back 5 | 1673 | Atalanta |
| Gerard Deulofeu | 7.73 | Back 5 | 1952 | Udinese |
| Ciro Immobile | 7.70 | Back 4 | 2711 | Lazio |
| Dušan Vlahović | 7.55 | Back 4 | 1857 | Fiorentina |
| Tammy Abraham | 7.47 | Back 5 | 1984 | Roma |
| Marko Arnautović | 7.21 | Back 4 | 534 | Bologna |
| Edin Džeko | 7.21 | Back 5 | 2462 | Inter |
| Lautaro Martínez | 7.16 | Back 5 | 2273 | Inter |
| Victor Osimhen | 7.15 | Back 4 | 1959 | Napoli |
| Marko Arnautović | 7.15 | Back 5 | 2160 | Bologna |
| Tammy Abraham | 7.03 | Back 4 | 1100 | Roma |
| Nicolò Zaniolo | 7.00 | Back 5 | 928 | Roma |
| Riccardo Orsolini | 7.00 | Back 5 | 601 | Bologna |
Conditions for the presented data:
– Minimum minutes played in the season: 450 minutes (equivalent to 5 full games) per type of defense played (Back 4 or Back 5);
Data from FBref.