After successive years in which Juventus were champions, the two Milanese teams managed to win the title. The year after Inter’s conquest, AC Milan managed to win the championship. Despite this, the 2021-2022 Season has a CB from Napoli with an average rating much higher than its counterparts: Kalidou Koulibaly.
| Player | Rating | Defense | Minutes Played | Team |
| Kalidou Koulibaly | 7.89 | Back 4 | 2315 | Napoli |
| Roger Ibañez | 7.31 | Back 5 | 1800 | Roma |
| Lucas Martínez Quarta | 7.25 | Back 4 | 1379 | Fiorentina |
| Pierre Kalulu | 7.24 | Back 4 | 1440 | Milan |
| Fikayo Tomori | 7.2 | Back 4 | 2718 | Milan |
| Milan Škriniar | 7.2 | Back 5 | 3150 | Inter |
| Alessandro Bastoni | 7.16 | Back 5 | 2311 | Inter |
| Gleison Bremer | 7.14 | Back 5 | 2890 | Torino |
| Igor | 7.09 | Back 4 | 2231 | Fiorentina |
| Federico Dimarco | 7.04 | Back 5 | 1017 | Inter |
| Roger Ibañez | 7.02 | Back 4 | 990 | Roma |
Conditions for the presented data:
– Minimum minutes played in the season: 450 minutes (equivalent to 5 full games) per type of defense played (Back 4 or Back 5);
Data from FBref.