With a substantial increase in the number of Top Performing CBs in La Liga (compared to last years list), Barcelona have the highest number of CBs present in this list: 4. In the limited minutes playing at the CB position, Koundé was the player with the highest average rating.
| Player | Rating | Defense | Minutes Played | Team |
| Jules Koundé | 7.64 | Back 4 | 797 | Barcelona |
| Ronald Araújo | 7.54 | Back 4 | 1506 | Barcelona |
| Nacho | 7.49 | Back 4 | 752 | Real Madrid |
| Pau Torres | 7.38 | Back 4 | 3054 | Villarreal |
| Mario Hermoso | 7.37 | Back 4 | 540 | Atlético Madrid |
| Éder Militão | 7.32 | Back 4 | 2609 | Real Madrid |
| Nemanja Gudelj | 7.17 | Back 5 | 900 | Sevilla |
| Eric García | 7.14 | Back 4 | 1036 | Barcelona |
| Andreas Christensen | 7.13 | Back 4 | 1664 | Barcelona |
| Mario Hermoso | 7.11 | Back 5 | 1480 | Atlético Madrid |
| David López | 7.05 | Back 4 | 1264 | Girona |
| Unai Núñez | 7.04 | Back 5 | 450 | Celta Vigo |
Conditions for the presented data:
– Minimum minutes played in the season: 450 minutes (equivalent to 5 full games) per type of defense played (Back 4 or Back 5);
Data from FBref.