Despite Argentina winning Copa América, no CBs from their national team are present in this list. All the players in this list played in a Back 4.
| Player | Rating | Defense | Minutes Played | Country |
| Éder Militão | 8.12 | Back 4 | 270 | Brazil |
| Júnior Alonso | 7.67 | Back 4 | 480 | Paraguay |
| Thiago Silva | 7.32 | Back 4 | 450 | Brazil |
| José Giménez | 7.26 | Back 4 | 450 | Uruguay |
| Guillermo Maripán | 7.10 | Back 4 | 180 | Chile |
| Marquinhos | 7.09 | Back 4 | 540 | Brazil |
| Diego Godín | 7.01 | Back 4 | 405 | Uruguay |
Conditions for the presented data:
– Minimum minutes played in the competition: 180 minutes (equivalent to 2 full games) per type of defense played (Back 4 or Back 5);
Data from FBref.